Combining Microdosing (LSD, Psilocybin) With Medication Or Supplements
James Fadiman, PhD and Sophia Korb, PhD compiled a list of medications, supplements, and drugs that have been found not to cause any adverse side effects when combined with microdosing.
Notes of caution
This list does not guarantee that microdosing is safe and/or effective in combination with the listed medications.
- This list applies to microdosing with LSD and psilocybin only. Other microdosing substances may or may not combine well with your medication or supplements.
- If you take two or more medications, or have a somatic illness or a mental health condition, it is advised to consult a medical doctor or psychiatrist who’s well versed in psychedelics and medication interactions prior to microdosing.
- Always consult your MD or psychiatrist if you want to combine, taper or discontinue any of your medications.
What if my medication is not on the list?
If your medication is not on this list, this means there is insufficient data to support that microdosing is safe and/or effective. It is advised to consult a medical doctor or psychiatrist who’s well versed in psychedelics and medication interactions prior to microdosing.
Microdosing (LSD, Psilocybin) And Medications
To quickly search this list for your medication, use CNTRL + F (on PC) or COMMAND + F (on Mac) and type in your medication.
Painkillers
- Acetaminophen/paracetamol (Tylenol)
- Aspirin
- Codeine
- Dihydrocodeine (Co-dydramol)
- Hydrocodone (Vicodin, Norco)
- Ibuprofen (Advil, Motrin)
- Naproxen (Aleve)
Heart/high blood pressure medication
- Amiodarone (Cordarone, Nexterone)
- Hydrochlorothiazide (HCTZ, HCT)
- Lisinopril (Prinivil, Zestril)
- Losartan (Cozaar)
- Spironolactone (Aldactone)
- Telmisartan (Micardis, Actavis)
- Valsartan (Diovan)
- Ramipril (Tritace)
Birth-control
- Aubra
- Hormonal pills
- Marvelon
- Mirena
- Nuvaring
- Tricyclen
Antacid
- Ranitidine (Zantac)
Antibiotics
- Clindamycin (Cleocin, Dalacin, Clinacin)
- Doxycycline
- Minocycline (Minocin, Minomycin, Akamine)
- Penicillin (Bicillin)
Antifungals
- Fluconazole (Diflucan, Celozole)
Focus medication (ADHD/ADD
- Amphetamine (Adderall)
- Bupropion (Wellbutrin)
- Dextroamphetamine (Dexedrine, Metamina, Attentin, Zenzedi, Procentra, Amfexa)
- Lisdexamfetamine (Vyvanse)
- Methylphenidate (Ritalin, Biphentin)
- Modafinil (Provigil)
Sleeping
- Zopiclone (Zimovane, Imovane)
- Melatonin
- Zolpidem (ambien, stilnox)
Antihistamines
- Cetirizine (Zyrtec)
- Diphenhydramine (Benadryl, Gravol)
- Loratadine (Claritin)
- Ranitidine (Zantac)
Benzodiazepines (anxiety, sleep, seizure
- Alprazolam (Xanax)
- Clonazepam (Klonopin)
- Diazepam (Valium)
- Flurazepam (Staurodorm)
- Lorazepam (Ativan)
Other anxiolytic
- Etizolam
- Propranolol
Parkinson’s medication
- Levodopa
- Pramipexole
Cholesterol medication
- Atorvastatin (Lipitor)
- Rosuvastatin (Crestor)
Simvastatin (Zocor) - Statins
Racetams
- Aniracetam
- Phenylpiracetam
- Piracetam
Mood stabilizers and antipsychotics
- Aripiprazole (Abilify)
- Buspirone (Buspar)
- Lamotrigine (Lamictal)
- Quetiapine (Seroquel)
Diabetes
- Metformin (Glucophage)
Anticonvulsants
- Baclofen (Lioresal)
- Carbamazepine (Tegretol)
- Cyclobenzaprine (Flexeril)
- Gabapentin
- Mirtazapine
- Sodium valproate
- Tizanidine (Zanaflex)
- Primidone
- Topiramate
Thyroid medication
- Methimazole or Thiamazole
Antidepressants
- Bupropion (Wellbutrin)
- Citalopram (Celexa)
- Desvenlafaxine (Pristiq)
- Doxepin (Sinequan)
- Duloxetine (Cymbalta)
- Escitalopram (Lexapro)
- Paroxetine (Paxil)
- Sertraline (Zoloft)
- Venlafaxine (Effexor)
GERD
- Esomeprazole (Nexium)
- Pantoprazole (Protonix)
- Ranitidine (Zantac)
Breathing (asthma, COPD
- Salbutamol (Albuterol)
- Cetirizine (Zyrtec)
- Beclometasone (Clenil Modulite)
- Montelukast (Singulair)
Antiviral
- Nitazoxanide
Recreational drugs
- Alcohol
- Amphetamine (speed)
- Heroin
- Kratom
- Marijuana (cannabis)
- Nicotine
Anti-inflammatory
- Mesalazine (Octasa)
Immunosuppressant
- Hydroxychloroquine (Quensyl)
Erectile Dysfunction
- Tadalafil (Cialis)
Alcohol dependence treatment
- Acamprosate (Campral)
- Disulfiram (Antabuse)
- Naltrexone
Hormones and Steroids
- Norethindrone Acetate ethinyl
- Estradiol
- Prednisone (Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone)
- Estrogen (Premarin)
- Progesterone (Prometrium, Utrogestan, Endometrin)
- Testosterone
- Levothyroxine (Synthroid)
- Naturethroid
- Dexamethasone
DHEA
- Spironolactone (Aldactone)
Supplements
- 5-HTP
- Albizia
- Ashwagandha
- B100
- BCAAs
- Biotin
- Brahmi
- Bromelain
- Caffeine
- Calcium
- Cayenne
- Chaga
- Chlorophyll
- Choline
- CILTEP
- CoQ10
- Cordyceps
- Creatine
- Eleuthero
- EPA/DHA
- Fish oil
- Ginseng
- Glucosamine
- Iodine
- Iron
- Kelp
- Kratom
- L-theanine
- Lemon balm
- Lion’s Mane
- Maca
- Magnesium
- MCT
- Methyl sulfonyl methane (MSM)
- Milk thistle
- Multivitamins
- Omega 3/6/9
- Passionflower
- Phosphatidyl
- Probiotics
- Pycnogenol
- Reishi
- Rhodiola
- Rosacea
- Selenium
- Shatavari
- Skullcap
- St John’s wort
- Taurine
- Tulsi
- Turmeric (curcumin)
- Turkey’s tail
- Twynsta
- Vitamin
- B6
- B12
- D3
- K
- C
- K2
- D